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Loss of glial homeostasis, BBB disruption, tanycyte remodelling and neuronal resistance to insulin and leptin lock the system into a state of maladaptive #neuroinflammation

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[DOI] [PubMed] [Google Scholar] 253.Green S.J

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well-tolerated in mice, rats, rabbits, and dogs with no serious organ toxicity.[34][35] Clinical Safety : Mild local irritation possible at injection sites, but no systemic adverse effects reported in trials.[36][37] Potential Risks : Theoretical concerns include pro-angiogenic effects potentially promoting tumor growth, though no evidence supports this in studies.[38] Long-term human data is limited, so monitoring is advised