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436 Berberine not only enhances photodynamic therapy sensitization but also inhibits GBM proliferation by suppressing fatty acid synthesis and reducing EV secretion

Although regulation by redox environment occurs in the heterodimeric non-plant eukaryotic GCL, the plant GCL function as homodimeric enzymes with two intermolecular (not intramolecular) disulfide bonds (Hothorn et al., B
A specific effect of increased glycolysis in VSMCs is the stabilization of RUNX2 via lactylation [49], resulting in heightened HIF-1 activity, osteogenic differentiation of VSMCs, and promotion of vascular calcification and remodeling [130]

For example, curcumin appears to cause DNA damage at both the mitochondrial and nuclear levels, suggesting that it may have a carcinogenic effect at doses near those that show positive results

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