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However, recent evidence suggests that the GH produced locally by the colon tumor cells, and not pituitary GH, acts in an autocrine and paracrine manner to suppress the tumor suppressor proteins and to increase nuclear -catenin accumulation and epithelialmesenchymal transition potentially participating in tumor progression (46,47)

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Ensuring global research equity is equally vital, so that populations in low- and middle-income countries, which often face higher environmental exposures, are fully represented in data, policy decisions, and intervention efforts

Astragalus polysaccharide (APS), a biological macromolecule, is extracted from astragalus and has been reported to exhibit complex biological activities involved in intestinal barrier integrity maintenance, intestinal microbiota regulation, short-chain fatty acids (SCFAs) production, and immune response regulation, which are critical for intestine health