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T., Low A., Chappell A

Individuals with a common mutation in methylenetetrahydrofolate reductase (MTHFR) could also have significantly elevated plasma homocysteine levels (Frosst et al., 1995)

Timing relative to training or injury is non-negotiable

an active drug with a known efficacy profile is a useful method for evaluating new drugs while avoiding the ethical dilemmas associated with placebo 1 The study was not designed to compare efficacy or safety between groups 1 Patients were hospitalized with an acute exacerbation of schizophrenia and considered markedly ill, with mean PANSS total score at baseline of 94.1 (ARISTADA) and 94.6 (paliperidone palmitate) 1 Prior to the study, 31% of the subjects had a history of exposure to risperidone/paliperidone only, 6% of the subjects had a history of exposure to aripiprazole only, 50% of the subjects had a history of exposure to both, and 13% of the subjects had no exposure to either of the antipsychotics 1 Patients had to have a history of tolerated use of aripiprazole or risperidone/paliperidone, or demonstrated tolerability to prospective oral test doses during study screening 1 Study Limitations Interpretation of these findings is limited in the absence of a placebo arm 1 The data were collected in patients who met the specific ALPINE trial inclusion and exclusion criteria