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Rupalis interests include interstitial lung disease, particularly as related to oncologic drugs

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As described by Floh (2012), the speed of reactions within the enzyme-substrate complex for a Sec-Gpx are so fast that assumptions of Michaelis-Menten saturation-type kinetics are no longer viable, because in effect the enzyme cannot be saturated by substrate

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Remarkably, xCT-targeted drugs (Erastin and SSZ) only slightly affected SLC7A11 protein levels in A549 and KP cells but caused a greater decrease in LDHB KD cells ( Figure 3e, Supplementary Figure 6e )