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Longitudinal multi-omics profiling of high-altitude migrants reveals hypoxia-driven enrichment of Escherichia coli and Klebsiella pneumoniae strains harboring upregulated purF (amidophosphoribosyltransferase) expression while downregulated xdh (xanthine dehydrogenase)

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At the end of the incubation period, the medium was replaced with a substrate for UGT and MPA

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