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In humans, however, randomized trials with fertility endpoints are lacking

You may read more about it at the link below: Changes in receptor response by disease states Disease states may alter the number of available receptors , which can alter the sensitivity and response of a given cell or tissue

doi: 10.1152/ajplung.00525.2007

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Recurrent stress incontinence is associated with decreased neuromuscular function in the striated urethral sphincter