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Description
Our study indicates that SAC interferes with the interaction between Keap1 and Nrf2, stabilizing Nrf2 and promoting its accumulation in the nucleus, thereby activating the expression of downstream antioxidant genes such as NQO1 and GPX4
Electron-donating groups accelerate acid hydrolysis for faster payload release, while electron-withdrawing groups slow cleavage, enhancing plasma stability
In addition to, the involvement of polyphenols in multiple inflammatory signaling pathways, they also exert beneficial effects by acting on the intestinal epithelium
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& Wyngaarden, J
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