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also, it is associated with worse prognosis and aggressiveness [7, 8]

However, the molecular pathways by which anesthesia induces these deleterious effects is unclear

Csukly G, Sirly E, Fodor Z, Horvth A, Salacz P, Hidasi Z, et al

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The analysis that identified CHST3 as a candidate gene in disc degeneration involved a total of 32,642 human subjects of Southern Chinese descent, with 4,083 individuals with lumbar disc degeneration and 28,599 controls