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Funding The current work was supported by the National Natural Science Foundation of China (Grant No

Choline and L-carnitine that are not absorbed in the small intestine are metabolized by the gut flora into trimethylamine (TMA) in the colon and then oxidized to TMAO in the liver by Flavin-containing monooxygenase 3 (FMO3) ( Anaerococcus hydrogenalis , Clostridium asparagiforme , Clostridium hathewayi (Romano et al., 2015)

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ControlledRelease Capsules

While acknowledging that this was a relatively small retrospective study ( n = 81), the results suggest that in the future, pending further evidence, acetyl-l-carnitine might be considered as an addition to first-line treatments currently recommended by IASP