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CLA, L-Carnitine, and Green Tea Extract: The Combined Effect Taken together, these three compounds create a sequential, non-stimulant fat oxidation system: CLA reduces the rate at which fat is stored and partitions nutrients toward muscle tissue L-Carnitine ensures that mobilised fatty acids are efficiently shuttled into the mitochondria for oxidation Green Tea Extract (EGCG) elevates the rate of mitochondrial fat oxidation by sustaining thermogenic signalling Each compound addresses a distinct mechanistic bottleneck

Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide

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Additional information Authors' contributions EMC executed the experiments and wrote the manuscript