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Funding Statement The study was supported by the Comunidad de Madrid (P2022/BMD-7321), ProACapital, and HALEKULANI, S

Vit-D could also inhibit NF-B activation to down-regulate proinflammatory cytokine synthesis and other key activators of cell-mediated immunity 692

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Methazolamide: Although clinical trials of methazolamide in treating CMS are limited, animal studies revealed that it reduced Hb concentration, Hct, and blood viscosity in a dose-dependent manner

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Receptor Supersensitivity Blockade In the landmark 1997 Sikiric study published in Biological Psychiatry (PMID: 9547930), mice pretreated with haloperidol (a dopamine antagonist) developed behavioral supersensitivity to amphetamine challenge