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The core strategies include the following (Figure 5): (1) Supplement with glucosamine sulfate (1,500 mg/day) and chondroitin sulfate (8001200 mg/day) as precursors of cartilage matrix to promote cartilage repair

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While the body stores a certain amount of B12, long-term deficiency can develop gradually, particularly in individuals with restricted dietssuch as vegansor those with medical conditions that impair absorption, such as pernicious anaemia or gastrointestinal disorders like coeliac disease or Crohns disease

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Others stimulate the body's own growth hormone production