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HIV-1 Tat-mediated microglial activation by impairing mitophagy/autophagy Mitophagy selectively removes damaged mitochondria through a progression from phagophore to autophagosome and then to lysosome, thereby preserving organelle integrity and cellular homeostasis [82]

The downregulation of ChaC2 tends to decrease the levels of glutathione and blocks the self-renewal of these cells

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