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However, the compound has not undergone formal human clinical trials, and long-term safety data does not exist

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Kang HJ, Hong YB, Kim HJ, Rodriguez OC, Nath RG, Tilli EM, et al

Furthermore, UA self-assembled nanoparticles have been demonstrated to block tumor angiogenesis via the COX-2/VEGFR2/VEGFA axis while simultaneously upregulating TNF-, IL-6, and IFN- to activate immune responses (Fig

It was previously approved by the FDA for diagnostic evaluation and treatment of pediatric GH deficiency and is now widely used off-label in research and clinical settings to address adult-onset GH insufficiency and age-related hormonal decline
