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doi: 10.1007/s00204-019-02409-6

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stably passed a constructed E119V + I222L mutant in MDCK cells and compared its drug sensitivity to wild-type virus (influenza A virus H3N2)

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By contrast, those with the MTHFR A1298C CC genotype (homozygous mutant) tend to have higher folate concentrations without overt clinical symptoms, although vitamin B12 deficiency may be masked (63)