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Besides its cofactor role, NAD + is also a substrate for NAD + -consuming enzymes such as sirtuins (regulators of gene expression and longevity pathways) and PARPs, which mediate DNA repair and cellular stress responses
Although the applicability of these proteins as markers of intestinal damage relevant to CRC pathogenesis is still uncertain and the subject of current investigation, the use of biomarkers of microbial pathogenicity and gut-barrier status may help CRC prevention, screening, and patient management
doi: 10.1093/humrep/del261 27
