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Torsemide versus furosemide after discharge in patients hospitalized with heart failure across the spectrum of ejection fraction: findings from TRANSFORM-HF

This makes targeting the Nrf2GPX4 pathway a highly promising and important direction for developing OA disease-modifying therapies (Figure 1)

2020;135:e237e260

10.1016/j.vph.2018.02.010 100 VukojeviJ.VrdoljakB.MalekinuiD.SiroglaviM.MilaviM.KolencD.et al (2020)

PMID 13360274

In terms of ferroptosis, a research demonstrated that neutrophil ferroptosis in SLE patients was induced by the synergistic effect of autoantibodies and IFN-, leading to transcriptional repression factor CREM binding to GPX4 promoter and subsequent downregulation of GPX4 protein expression