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Wible and Sutter 2017), representing only about 23% of amino acids comprising the human proteome

(2025) 17:e89856

Peptide chains clump together into insoluble complexes that cannot be reversed by re-cooling

Sirt1, Sirt6 and Sirt7 are predominantly localised in the nucleus, while Sirt2 is found in the cytoplasm, and Sirt3, Sirt4 and Sirt5 are found in the mitochondria (Yu et al., 2022)
