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diet and lifestyle are the other pieces that complete the picture

Annu Rev Pharmacol Toxicol 43:23360 Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P (2002) Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Systemic Inflammatory Response Syndrome (SIRS) presents with shock and hyperpyrexia exceeding 41C

Changes in chromatin structure affect gene expression, which in turn plays a decisive role in cellular function and fate

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