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Animal studies suggest that local or systemic use of deferoxamine may significantly alleviate OA cartilage degradation and inhibit ferroptosis markers in chondrocytes by activating the Nrf2 pathway (54)

Vitamin B12 among vegetarians: Status, assessment and supplementation

Headaches can also fall into this category if they are more persistent than a mild, passing feeling

No serious adverse events have been documented in research literature

Given the similarities between POEMS syndrome and plasma cell dyscrasias such as multiple myeloma, it could be postulated that the mechanisms in POEMS syndrome causing vitamin B12 deficiency may be similar

Translation: drier, redder, and itchier skin