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In addition, we observe higher levels of malondialdehyde (MDA), protein carbonyls and 8-hydroguanosine (8-OHdG) DNA adduct, as hallmarks of cellular lipid, protein and DNA oxidative damage, respectively

Lipid-related metabolism: AML cells are dependent on OXPHOS [118,119,120], AML cells obtain free fatty acids from bone marrow adipocytes and utilize fatty acid oxidation (FAO) and OXPHOS to maintain AML cell survival and growth [121,122,123]

Anti-DR4 antibody (Abcam, Cambridge, UK), anti-DR5 antibody (Exbio, Praha, Czech Re-public) or anti-Transferrin antibody was immobilized with cells for 1 h

Statements Author contributions SC: Writing review & editing, Conceptualization

1995;40(Suppl):63S-80S

5-Amino-1MQ Summary 5-amino-1MQ is a cell-permeable analogue of methylquinolinium that has been studied for its ability to inhibit nicotinamide N-methyltransferase