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Instead of focusing on single genes, considerable emphasis has been placed on utilizing data-driven frameworks at the system or network level to generate biologically/clinically meaningful gene modules comprising sets of functionally associated genes whose homeostasis may be altered by specific pathophysiological events 15,16,17,18,19

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Subsequently, bacteria and LPS are translocated into the liver through the portal vein, activating the TLR4/NF-B signaling pathway of liver Kupffer cells, and promoting the production of inflammatory cytokines such as TNF-, IL-6 and IL-1 (Jiang and Schnabl, 2020)

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