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the imine derivative a2 was most potent (IC50: 7.21 M, 27.36 M, 2.76 M, respectively), consistent with docking, MD, and MM/GBSA analyses
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Gene expression analysis showed significantly reduced expressions of PRX1 and caspase-3 in the pretreatment groups when compared with cells treated with H2O2 alone
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During this time, the duration of immobility of the animal is observed
