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Toxins in urine have been found to increase oxidative stress markers and worsen renal functions such as retention solute, increased F2-isoprostanes, malondialdehyde, and asymmetric dimethylarginine (Tyagi et al

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Van RaamsdonkLWDVan Der ZandeMKoelmansAAHoogenboomPLAPetersRJBGrootMJet al

Separation of TM lobes and rearrangement of residues around the heme-binding pocket cause the release of heme either towards the periplasmic space or to the periplasmic bilayer leaflet of the membrane
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