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Blakemore, Crosstalk between glia Inflammation-related cytokines and molecules In the cuprizone model severe microglial accumulation and astrogliosis are promoting an intensive inflammatory response (Blakemore, 1998) associated with the expression of a battery of inflammatory cytokines and chemokines including pro-inflammatory molecules such as TNF-, interleukin-1 (Il-1), interferon- (IFN-), and nitric oxide (NO) (Hiremath et al., 1998

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doi: 10.1093/ajcn/66.1.116