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575 Investigations to find out possible predictors of response to immunotherapy blockade have revealed that PD-L1 expression, tumor mutational burden, 576,577 tumor intrinsic oncogenes, such as IFN-, p53, and Wnt signaling, 578,579,580,581 signatures of T cell dysfunction and antigen presentation expression, 582,583,584,585,586 gut microbiota and its derived metabolites 587,588,589 are all significantly associated with clinical benefit

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10.3390/cancers6041890 [DOI] [PMC free article] [PubMed] [Google Scholar] Kim T

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