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On this ground the WHO updated its DR-TB treatment guidelines in 2022 (WHO Consolidated Guidelines on Tuberculosis, 2024), recommending the 6-month BPaL-M regimen for MDR/Rifampicin-Resistant (RR)-TB in patients unexposed to bedaquiline, pretomanid, or linezolid (Johnson et al., 2024)

Further investigation is needed to determine whether BDNF acts as a retrograde messenger that modulates synaptic signals to lesioned RGCs

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Abstract Although iron accumulates in brain regions impacted by neurodegenerative diseases such as Alzheimers and Parkinsons, how chronic elevated iron levels contribute to neuronal dysfunction remains unclear

10.3390/antiox12030663 Antioxidants

One way that this reduction might occur is through desensitization, disassociation, or cointernalization of the dimer