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Kirkemo A, Peabody M, Diokno AC et al: Associations among urodynamic findings and symptoms in women enrolled in the interstitial cystitis data base (icdb) study
[PubMed 26943644] 6

It shook my faith in how these decisions were being made. CNNs Amanda Sealy and Raenu Charles contributed to this report.
The observed antinociceptive effects decreased when the -opioid receptor antagonist naltrexone was administered intraperitoneally, suggesting that these effects are primarily -opioid receptor mediated
This was compared to a 3.1% weight loss in those taking a placebo