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Figure 9 3.8 Proposed substrate recognition and enzyme mechanism of MSA-DH The potential substrate binding site of MSA-DH was explored by superimposing the three-dimensional structure of human succinic semialdehyde dehydrogenase in complex with its substrate (PDB ID: 2W8Q) (Kim et al., 2009) (Supplementary Figure S1)

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Total mTOR protein expression was increased in participants in the L-Carnitine-combination group at the end of the study compared to the baseline ( P = 0.017)

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