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These hypotheses should be presented as unresolved research questions rather than settled conclusions

These findings detail mechanisms of NRF2-dependent transcriptional regulation, pointing to noncanonical roles that extend beyond augmenting antioxidant capacity

Similarly, ERK (extracellular signal-regulated kinase) and its involvement in melanin synthesis via the ERK/CREB (cAMP response element binding protein) pathway demonstrate how kinases contribute not only to antioxidant defense but also to pigmentation regulation by upregulating MITF and TRP1 69,71

Although diet can be a cause, there are also many other possible causes of vitamin B12 deficiency

Acta Haematol 87:7174 Taher A, Isma'eel H, Mehio G et al (2006) Prevalence of thromboembolic events among 8,860 patients with thalassaemia major and intermedia in the Mediterranean area and Iran

The reverse, adding too little water, creates an overly concentrated solution with the same problem in the opposite direction