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Primary antibodies were obtained as follows: Anti- ER-alpha, Anti-PARP, Anti-Cleaved Caspase-3, Anti-PARP and Anti-P-SAPK/JNK were from Cell Signaling (Danvers, MA, USA), Anti-4HNE and Anti -actin was from Abcam (Toronto, ON, Canada), Anti-GAPDH and Anti--Tubulin was from (Sigma), Anti-Nrf2 (H-300) and Anti-NQO1 (A180) were from Santa Cruz (Santa Cruz, CA, USA), Anti-Calnexin was from Enzo Life Sciences (Farmingdale, NY, USA) and Anti-GPR30 was from Genscript (Piscataway, NJ, USA)

N-acetylcysteine (NAC) was introduced in the 1960s as a mucolytic drug for chronic respiratory diseases

There are several different forms of L-arginine supplements

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