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However, internal production can be slowed down by several factors

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R., Skottner, A., Harris, A

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The lessons learned from astrocyte-targeted strategies provide a natural transition to examining microglia, whose dual role as immune defenders and potential drivers of pathology makes them equally compelling therapeutic targets (Figure 5)

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This stabilization results in the exposure of DELE1s C-terminal domain to the cytosol, where it interacts with and activates the HRI-ISR pathway

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