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AOD 9604 demonstrates a favorable safety and pharmacokinetic profile across multiple toxicology and clinical studies

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[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations

Two studies using high throughput screening discovered active compounds with IC50 in the nanomolar range [78-79]