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Tsikas and Duncan 2014)
Moreover, the use of CB-839 in combination with ABT-199 (BCL-2 inhibitor) facilitated mitochondrial depolarization, decreased cellular oxidative phosphorylation capacity, and induced apoptosis in OCI-AML2 and MORM-14 cell lines [20]
Dosages used in the reviewed studies ranged from 600 to 3600 mg per day for 8 weeks to 1 year, with studies using dosages of 10002000 mg per day showing the best responses
Griendling, K
Effect of mucolytic and expectorant drugs on tracheobronchial clearance in chronic bronchitis
