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Based on this analysis, tumor cells demonstrated a significantly higher signaling entropy ratio post nivolumab plus ipilimumab (Fig

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Furthermore, exploiting antioxidant vulnerabilities through aldehyde dehydrogenase (ALDH) inhibition with agents like disulfiram, or glutathione peroxidase 4 (GPX4) inhibition, can induce ferroptosis specifically in DTP populations, further reducing residual tumor burden (Raha et al., 2014)

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Fracanzani AL, Burdick L, Raselli S, et al