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doi: 10.1038/s41522-025-00734-6

Marked thrombosis, arterial and venous, peripherally and centrally, occur as prominent stasis and vessel failure progress (i.e., congested inferior caval vein and superior mesenteric vein, failed azygos vein unable to serve as a rescuing pathway with direct delivery to the superior caval vein [14,15,16,17,18,19,20,21,22,23])

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Occasional mild fatigue may occur early in treatment but usually improves with continued use

Vigorously wipe the rubber stoppers on both the PT-141 vial and the bacteriostatic water vial with an alcohol prep pad

This functional deficiency disrupts methylation and homocysteine metabolism, leading to symptoms resembling B12 or folate deficiency