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However, copper peptides should not be mixed directly with high-dose vitamin C or strong AHA/BHA formulations in the same application step, as these can chelate copper ions and reduce efficacy

Potential Side Effects and Limited Human Data While preclinical studies have not shown significant toxicity at standard doses, the research in humans is still in its early stages

Doses above 100mg daily show diminishing returns in NNMT inhibition the enzyme inhibition curve plateaus beyond 150mg while increasing the risk of methylation pathway disruption and homocysteine elevation