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Novel biological affinity ligands can be obtained through in vitro selection techniques such as phage, ribosome or yeast display (Smith and Petrenko, 1997), with phage display being very popular for these purposes

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Discovery of GS-9131: design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148

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pneumoniae infection and mortality (33)

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A Sal I site was introduced following the MBP residue A369

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