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In addition, circadian rhythm could have important consequences for physiological outcomes of chemical exposures (e.g., herbicide application) at different times of the day (Hooven et al., 2009)

Segura emphasized that the work went beyond compliance

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If the ability to reduce GSSG to GSH is overwhelmed by a high burden of oxidative stress, GSSG can be exported out of cells or react with protein sulphydryl groups to prevent a major shift in the redox equilibrium [11], thereby depleting cellular GSH

The study was performed by subjecting adjuvant-induced arthritis (AIA) rats to fractionated WBI (6 Gy of -rays: 2 Gy/fraction once per week for 3 consecutive weeks) and treating them with ebselen (20 mg/kg/day)

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