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Additionally, SIRT3 can activate the transcription factor ATF4 to regulate the transcription of SLC7A11 (67)

These results further suggest that a balanced generation of ROS by mitochondrial complex I is crucial to maintain MNA cellular fitness

Gigault, J

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Interestingly, tBHQ, which is a compound added to foods and cosmetics as a preservative, induces Nrf2 and robustly increase xCT protein levels.[ref] Considering that increasing xCT can cause more glutamate in the synapse, it makes sense that this preservative is linked to ADHD and hyperactivity in some children.[ref] Regulation of Glutamate Transporter Levels: The availability of glutamate transporters in astrocytes and other glial cells depends on a number of different factors