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Piteau S, Olver A, Kim SJ et al (2007) Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat

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Presuming that the putative high-folatelow-vitamin B-12 interaction on serum holoTC and the metabolic markers of vitamin B-12 status is due to excess folic acid, an important consideration is at what level of exposure might these effects become metabolically and clinically relevant