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Consequently, advisable to reconsider reviewing current proton pump inhibitor prescription and consider - - whether proton pump inhibitor prescription is still required, - if suppression of gastric acidity is still required then could it be managed with an H2 antagonist such as ranitidine (there is a general belief that they cause less nutritional harm than proton pump inhibitors)

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Hence, the current study aimed to investigate the role of miRNA-373/P2X7/NLRP3/NF-B trajectory in its pathogenesis as well as the possible anti-inflammatory effects of probenecid and l-carnitine in ameliorating osteoarthritis via modulating this pathway