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Cysteine, a conditionally essential amino acid, is normally synthesised from methionine through a multi-step process, but its synthesis can be compromised under specific pathophysiological conditions [120]

On the basis of theoretical considerations, it was hypothesized that the operon encodes for a malic semialdehyde dehydrogenase (MSA-DH) which enables for the subsequent conversion of MSA into L-malate which might be channelled into the tricarboxylic acid cycle (Zhu et al., 2014)

Our mitochondria can be affected by other types of free radical build-up as well

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Given the illegal nature of AAS use in many settings and the ethical impossibility of conducting long-term interventional studies with supraphysiological androgen doses in humans, a substantial proportion of cases likely remain unreported, and the true prevalence of this phenomenon may be underestimated in the existing literature

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