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18 mTORC1 integrates signals from nutrients and growth factors to regulate various anabolic processes, including protein synthesis, nucleotide production, lipid biosynthesis, and glycolysis, while inhibiting catabolic processes such as autophagy by phosphorylating ULK1/2 and sequestering lysosomal enzymes

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Pink to red thread-like skin markings caused by dilation and breakage of superficial blood vessels ( telangiectasia , sometimes called spider veins) are another common feature of rosacea

p53-mediated adaptation to serine starvation is retained by a common tumour-derived mutant

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