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For vitamin B 12 labeling purposes, 100% of the daily value was 6.0 g, but on 27 May 2016, it was revised downward to 2.4 g (see Reference Daily Intake)

The degeneration may be in the form of lesions in the central nervous system, as in multiple system atrophy (MSA), or in loss of autonomic nerves not involving the central nervous system, as in pure autonomic failure (PAF)

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