glp-1 drugs metformin TrimRX Emerging research suggests that GLP-1

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The most commonly reported effects include: Nausea the most common, typically peaks in the first 48 weeks and decreases significantly as the body adjusts Reduced appetite expected and intentional

Abbreviations CVE: Cardiovascular event EHR: Electronic health record GLP-1RA: Glucagon-like peptide-1 receptor agonist MACE: Major adverse cardiovascular events NAFLD: Non-alcoholic fatty liver disease NASH: Non-alcoholic steatohepatitis PCI: Percutaneous coronary intervention PSM: Propensity score matching SGLT2: Sodiumglucose cotransporter 2 SMD: Standardised mean difference TG: Triacylglycerol References Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M (2016) Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes

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Thats the detail most coverage of this story has buried under the financial and regulatory framing

The immediate priority is to address the drug delivery challenge