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[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Dhiman N., Awasthi R., Sharma B., Kharkwal H., Kulkarni G.T

Curcumin inhibits DNMTs both directly and indirectly

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Accordingly, immunosuppression hampers the elimination of senescent cells, which results in a negative feedback-loop on immunosuppressive cells, enhancing their release of inflammatory cytokines and ROS, thereby modulating other immune cells, inhibiting the immune response, and impairing tissue homeostasis [259, 260]

Telomerase Activity Support Research interest in Epithalon centers on its ability to support telomerase activity, the enzyme that maintains protective telomeres at the ends of chromosomes

221,222 IKK phosphorylates IB, which subsequently undergoes ubiquitylation and degradation, inducing NF-B and inflammatory reactions