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The Th1 response is characterized by production of IFN- which activates the bactericidal activities of macrophages and induces B cells to make antibodies, which in turn leads to cell-mediated immunity

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And dosing across the standard escalation schedule produces round numbers that are easy to draw: Clean, whole numbers at every dose level

To better understand the mechanisms of these disorders related to therapy, further research in the future is required on what causes the development of dysbiosis and depression, as well as drug-microbiota interactions

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