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Acknowledgements The authors thank Kristen Ewell for tissue sectioning, Yanling Lin and Chrislyn Andres for technical assistance, and Chris Zarow and Linda Chang for helpful comments and suggestions

This is partly why biohackers and longevity enthusiasts are interested in this small molecule, Cohen said

Ongoing trials (eg, TAME trial for Metformin, D+Q trials for aging-related diseases) will provide critical insights, but more diverse human studies are required.127 Bioavailability Challenge: In terms of translational application, bioavailability remains a significant challenge for many senolytic compounds, particularly plant-derived polyphenols such as fisetin and quercetin, which exhibit poor oral absorption, rapid metabolism, and low systemic retention